The Absorption of Oleic Acid in the Bile Fistula Rat.

نویسندگان

  • D R SAUNDERS
  • A M DAWSON
چکیده

A technique is described for collecting thoracic duct lymph in a portable glass saddle from an unrestrained rat. Uniformly labelled oleic acid in various physical states was given to rats with thoracic duct and bile fistulae to study the influence of bile salts on the amount absorbed and on the route of transport and esterification after absorption. It is suggested that in addition to their emulsifying action bile salts may stimulate the esterification of absorbed oleic acid by the intestinal mucosa.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Stereoselective Permeation of Tretinoin and Isotretinoin through Enhancer-Treated Rat Skin. II. Effects of Lipophilic Penetration Enhnacers

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

متن کامل

Stereoselective Permeation of Tretinoin and Isotretinoin through Enhancer-Treated Rat Skin. II. Effects of Lipophilic Penetration Enhnacers

Many properties of chemicals depend on their stereochemistry. Among these, the effects of stereoisomerism on percutaneous absorption of drugs are not well studied. We have previously shown that permeation of tretinoin and isotretinoin (two geometric isomers) through hydrophilic enhancers-treated rat skin is stereoselective. As, depending on their lipophilicity, penetration enhancers can change ...

متن کامل

Monoglyceride modification of jejunal absorption of fatty acid in the rat.

The effect of increasing the intracellular pool of monoolein upon the subsequent uptake and esterification of oleic acid was investigated using in vitro rat jejunal slice techniques. The mucosal pool of monoglyceride was expanded by preincubation of jejunal slices in a monoglyceride-containing bile salt medium at a temperature close to 1 degrees C, which inhibited esterification. Subsequent inc...

متن کامل

Intestinal absorption in vivo of micellar and nonmicellar lipid.

KNOEBEL, LEON K. Intestinal absorption in vivo of micellar and nonmicellar Zipid. Am. J. Physiol. 223(2) : 255-261. 1972.-Lymphatic transport of absorbed fatty acid and rate and site of uptake from intestinal lumen were measured in bile-fistula rats which received the lipid mixture, 10 mM oleic acid and 10 mM monoolein, by steady intraduodenal infusion. The concentration of fatty acid solubiliz...

متن کامل

The Effect of Titanium on Oleic Acid Transport in Rat EGS

Ani M1, Moshtaqi AA1, Ahmadvand H2 1. Assistant Professor, Department of Clinical Biochemistry, Faculty of pharmacy, Isfahan University of Medical Sciences 2. Assistant Professor, Department of Clinical Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences Abstract Background: There are reports indicating that fatty acid transport is affected by many biochemical paramete...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Gut

دوره 4  شماره 

صفحات  -

تاریخ انتشار 1963